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Friday, November 2, 2018

Adults use Juul e-cigarettes for their intended purpose — to quit smoking — even as teen use surges

Larry McLaughlin bought his wife a Juul e-cigarette for Christmas as a stocking stuffer two years ago.

While she didn't care for it, he did. And nearly two years later, the 62-year old construction worker still puffs on mango-flavored nicotine pods every day. It's the first time in more than 40 years of smoking and at least a dozen attempts to quit that McLaughlin, who lives in suburban Chicago, has successfully stopped smoking tobacco.

Juul founders Adam Bowen and James Monsees created Juul to do just that: help themselves and other adults stop smoking. But it's gotten a bad rap in recent months as federal health regulators question whether its popular candy flavors — including mango, creme and fruit — are at least partly responsible for the 77 percent surge in e-cigarette use among high school students over the past year.

Stories like McLaughlin's is what Juul wants to hear more of — not the ones about teens usage. Juul CEO Kevin Burns told CNBC that Juul isn't supposed to be cool for kids or hook non-smokers on nicotine. "It's not designed for them. It's not meant for them," he said.

Adults like McLaughlin are Juul's target market, and anecdotal evidence suggests it is helping some long-time cigarette addicts quit smoking as the product was intended.

Juul "was designed to replicate the nicotine experience and take away the combustion associated with smoking. And frankly, the product works," said Burns, who was previously Chobani yogurt's chief operating officer.

Quitting smoking is challenging, even though the risks are widely known. Cigarette smoking kills about 480,000 Americans every year, making it the leading cause of preventable death. The medical costs associated with smoking-related health problems are a staggering $170 billion a year, with an additional $156 billion in lost productivity from premature death, according to the Centers for Disease Control and Prevention.

While just 15.5 percent of U.S. adults smoked in 2016, that equates to about 38 million people, according to the agency's most recent data. Roughly 68 percent of adults who smoked wanted to quit, according to the CDC. About 55 percent of the adult smokers surveyed had tried to quit but only 7.4 percent succeeded.

Quitting smoking has almost immediate benefits, according to the American Lung Association. Within 20 minutes, heart rates normalize and, after two to three weeks, the risk of heart attack begins to drop, according to the group. Within a year, the risk of heart disease is half that of a current smoker. The risks of dying from lung cancer, getting bladder cancer and other cancers all fall the longer a former smoker stays tobacco free. Within 15 years, a former smoker's risk of heart disease is the same as a lifelong non-smoker, according to the health advocacy group.

Nicotine, by itself, is addictive. While it's not considered harmful, it's also not completely benign. Because e-cigarettes don't undergo combustion, the name for the chemical process that occurs when tobacco burns and releases toxins, they're inherently less dangerous than cigarettes. But e-cigarettes may pose their own long-term health risks, the National Academies of Sciences, Engineering, and Medicine has concluded.

Erika Sward, the American Lung Association's assistant vice president of national advocacy, said more research needs to be done on e-cigarettes.

"Comparing the safety of e-cigarettes to cigarettes in many ways is a fool's errand because the cigarette is the deadliest consumer product on the market," she said. At the same time, there just isn't enough information on e-cigarettes to fully assess their potential health risks, she said.

Research has shown that nicotine impacts the developing brain of adolescents differently than adults, triggering depression, anxiety or trouble focusing. And kids who use e-cigarettes are more likely to try regular cigarettes, the National Academy of Medicine found.

The FDA has embraced e-cigarettes as a possibly less risky alternative for adult smokers, though it has said weaning adults off tobacco can't come at the expense of hooking teens on nicotine.

"If we can switch every adult smoker fully to e-cigarettes, it would have a huge public health impact," FDA Commissioner Dr. Scott Gottlieb said in an interview.

Ryan Storey knew cigarettes caused diseases like lung cancer, heart disease and diabetes when he started occasionally smoking at age 17 during breaks as a cashier at Kroger. By the time he was 18, he was up to one to one-and-a-half packs of Marlboro Reds a day.

Storey, who lives in Louisville, Kentucky and is now an auto technician, said he tried quitting cold turkey a few times. It never worked. At one point, he tried switching to a tank-based e-cigarette. He hated it. Earlier this year, a friend recommended Storey try Juul's mango pods.

In the first three weeks, Storey said he didn't smoke a single cigarette. Now two months in, he said he's had a few but he hasn't bought a pack since he started "Juuling."

"I've had a couple of cigarettes here and there, and every time I put one in my mouth and bite it and smoke it, it tastes awful," said Storey, now 25. "I think to myself, why did I do this for eight years? How did I put up with this for eight years?"

Founders Monsees and Bowen, who met as product design grad students at Stanford University, designed the Juul to be something they thought would be appealing to smokers. It's a sleek device that allows users to simply pop in a pre-filled cartridge of nicotine liquid, which comes in flavors ranging from Virginia tobacco to fruit.

Launched just three years ago, Juul currently accounts for 75 percent of the e-cigarette market, according to Nielsen data from a recent four-week period.

While Juul is wildly popular, it is still unclear whether it can reliably help wean adults off tobacco. More research needs to be done before doctors really know, said Dr. Nancy Rigotti, a professor of medicine at Harvard Medical School and director of the tobacco research and treatment unit at Massachusetts General Hospital.

"We need a way to find out if Juul works for cessation, and if it does, we want to have it around but at the same time keep it out of the hands of kids," Rigotti said

Juul points to survey data showing about half of the people who reported smoking cigarettes when they started using Juul said they had switched because of the device.

Thirty-two-year old Travis Barker said he was feeling tired and winded after 12 years of smoking. So he tried Juul. He went four months without smoking a single cigarette, until the digital sculptor's work became really stressful and he temporarily regressed back to two packs of cigarettes a day.

He's back to Juuling again, but admits he hasn't been able to totally shake cigarettes. He said he still smokes on occasion at parties on the weekends.

"To me, it's not that I'm a 100 percent nonsmoker, but I cut down the tobacco that I do use. To me, that's a plus," Barker said. "If it eventually leads me to being a 100 percent nonsmoker forever, great. If all it does is cut me back, that's fine, too."

Health professionals say there is no safe amount of smoking. Some worry that e-cigarettes are creating dual users like Barker, or people who smoke both e-cigarettes and conventional cigarettes. They say more research needs to be done to determine whether that is just a natural phase in quitting.

Juul also needs to prove to regulators it can help adults stop smoking while stemming the recent spike in kids using its nicotine pods. Preliminary federal data show the number of high school students using e-cigarettes surged 77 percent this year with about 20 percent, or 3 million, saying they used the devices within the last 30 days.

Gottlieb has threatened to pull flavored products from the market and to require some products to undergo FDA review. The FDA also is considering confining sales to vape shops to make it harder for kids to buy. Juul and other e-cigarette makers have until Nov. 11 to submit plans to the FDA on curbing teen use.

Tobacco giant Altria in October said it would remove its MarkTen pod-based products and stop selling all flavors except for menthol or tobacco in its cig-a-like products until the FDA reviews and approves them. Juul has not yet publicly disclosed its plan.

"I've said many times, this opportunity [to curb adult smoking] can't come at the expense of addicting a whole new generation to nicotine," Gottlieb said, "and that's precisely what we're seeing happening."

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